Zonegran for weight loss reviews
Zonegran may interact with other medicines that make you sleepy (such as cold or allergy medicines, sedatives, narcotics, sleeping pills, muscle relaxers, and medicines for depression or anxiety ), carbamazepine phenobarbital, phenytoin, topiramate, or cold or allergy medicines that contain antihistamines. Once a stable dose is reached, steady state is achieved within 14 days. The precise mechanism(s) by which zonisamide exerts its antiseizure effect is unknown. Zonisamide may produce these effects through action at sodium and calcium channels. Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum. Zonisamide demonstrated anticonvulsant activity in several experimental models. This is not a complete list of side effects and others may occur. The relevance of these models to human epilepsy is unknown. Zonegran is supplied for oral administration as capsules containing 25 mg or 100 mg zonisamide. In animals, zonisamide was effective against tonic extension seizures induced by maximal electroshock but ineffective against clonic seizures induced by subcutaneous pentylenetetrazol. Zonegran in Detail - Patient Information: Side Effects. Furthermore, zonisamide suppressed both interictal spikes and the secondarily generalized seizures produced by cortical application of tungstic acid gel in rats or by cortical freezing in cats. Thus, zonisamide does not appear to potentiate the synaptic activity of GABA. Zonegran passes into breast milk and may harm a nursing baby. Tell your doctor all medications and supplements you use.
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The dose of Zonegran is 25 mg or 100 mg capsules administered orally once or twice daily. However, as a carbonic anhydrase inhibitor, zonisamide may cause metabolic acidosis (see WARNINGS, Metabolic Acidosis. Zonisamide extensively binds to erythrocytes, resulting in an eight-fold higher concentration of zonisamide in red blood cells than in plasma. Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself. All Consumer Professional Pill ID Interactions News FDA Alerts Approvals Pipeline Clinical Trials Care Notes Encyclopedia Dictionary Natural Products. Talk to your doctor about using birth control, and tell your doctor if you become pregnant during treatment with Zonegran. Tell the doctor immediately if you notice serious side effects of Zonegran including increased or worsening seizures, lightheadedness, shortness of breath, rapid heart rate, trouble concentrating, fever, chills, sores in your mouth and throat, severe pain in your lower back, blood in your urine, feeling very thirsty or hot, being unable to urinate, or severe skin reaction. The contribution of this pharmacological action to the therapeutic effects of zonisamide is unknown. Zonisamide raised the threshold for generalized seizures in the kindled rat model and reduced the duration of cortical focal seizures induced by electrical stimulation of the visual cortex in cats. Zonegran (zonisamide) is a sulfonamide anticonvulsant and a carbonic anhydrase inhibitor indicated as adjunctive therapy in the treatment of partial seizures in adults with epilepsy. Call your doctor for medical advice about side effects. Each capsule contains the labeled amount of zonisamide plus the following inactive ingredients: microcrystalline cellulose, hydrogenated vegetable oil, sodium lauryl sulfate, gelatin, and colorants. You may report side effects to FDA at 1-800-FDA-1088. Protein binding of zonisamide is unaffected in the presence of therapeutic concentrations of phenytoin, phenobarbital or carbamazepine.
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